One evening, police detective Tom Canboro (Gary Busey) finds himself battling more than thieves and thugs as he becomes entangled in the activities of an underground group who possess frightening psychic powers. As these powers are unleashed upon his family, Tom rushes to the rescue of his wife (Sheri Miller), his sister (Margot Kidder) and his brother-in-law (Howie Mandel). Before he can reach them however, a mysterious force takes control of his car and rushes him headlong into an oncoming truck.

There is nothing but blackness.

Tom wakes up -- years later -- in a hospital bed. As he staggers to consciousness, he finds himself in a world unlike anything he could have ever imagined. Is the devil really running the world, or is Tom still lying in that bed, with all of this nothing more than a creation of his badly damaged brain?

It doesn't take Tom long to realize that Franco Macalusso (Nick Mancuso) is no dream. The world has changed dramatically, and there may be no other explanation than the fact that Bible prophecy is coming to pass right before his eyes! Millions have disappeared and no one who has been left behind can even remember that they ever existed! The mark of the beast is everywhere and those who have not accepted it are being ruthlessly hunted down. The most wanted is Helen Hannah (Leigh Lewis) and her band of Christian believers who are exposing this self-proclaimed Messiah as the devil himself.

In the midst of all this, Tom discovers that his wife is still alive, and has become a part of this underground resistance, known to the world as the 'haters'. Pursued every step of the way by the same dark forces that he encountered before the rapture, he finds himself in an intense physical, mental and spiritual journey -- with the souls of millions hanging in the balance.